Description
Kidney disease is a major health issue worldwide, while the risk of kidney failure is still underestimated. Organ-on-chip is an ideal tool to study human disease and has great potential in biomedical applications such as drug screening, regenerative medicine and pre-clinical studies, because it has the capability of reproducing the 3D microenvironment as in the human body, for example by applying well-controlled fluid flow and other cues.
In this project, we focus on the kidney functioning unit – the nephron, and aim to mimic it on function level through developing "kidney-on-chip" - a microfluidics enabled bioreactor in which a physiologically-alike renal tubule-blood capillary interplay model is presented.
The "kidney-on-chip" will be firstly fabricated by optimizing different organ-on-chip fabrication techniques. After the renal cell seeding, the microfluidic mechanical bioinfluence on cell morphology and cell function will be investigated.
Researchers
Researcher: Sha Lou.
Supervisors: Carlijn V.C. Bouten, Jaap den Toonder.
Funding by RegMed-XB Kidney Moonshot.
Contact
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Zara SaidMohammed de HaanVermeulensteeg3055AK Gemondelaurens.ulrich@ yahoo.nl
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Olaf AvciAngelina von Heinrich d'OmóróviczaHendriksboulevard8226HJ Vinkenbuurtsenna.tran@ martenavanburmaniavegilinvanclaerbergen.org
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mr. Mike Gellemeyer ADLex Abdivan der Veldensingel7051JB Ryptsjerkdewit.fabian@ hotmail.nl