Christian Ottmann
Department / Institute
Group
RESEARCH PROFILE
Christian Ottmann is Associate Professor of Molecular Cell and Structural Biology at the department of Biomedical Engineering (research group Chemical Biology). He works on small-molecule modulation of Protein-Protein Interactions (PPIs) with a special focus on stabilization of 14-3-3 adapter protein PPIs. He is involved in several early drug discovery projects with the pharmaceutical industry, targeting disease as diverse as cancer, Alzheimer’s disease, inflammation and cystic fibrosis. In this context he also is coordinator of the FP7 Industry-Academia Partnership and Pathways (IAPP) 14-3-3STABS and the Horizon2020 European Training Network (ETN) TASPPI.
As a scientist I feel that I have to give something back to society. I am doing that by helping to solve hard-to-crack biomedical problems such as drugging protein-protein interactions.
ACADEMIC BACKGROUND
Christian Ottmann studied Biology (Dipl.) at the Ruhr-University in Bochum (Germany). From 1999-2003, he did his PhD research at the Eberhard-Karls-University of Tübingen under supervision of Prof. Claudia Oecking and graduated summa cum laude. From 2003-2004, he was a Postdoctoral Research Assistant with Prof. Oecking. Beginning of 2005, he founded the biotech company AmbAgon Technology in Dortmund, Germany. In 2006, he became a group leader at the Chemical Genomics Centre (CGC) of the Max Planck Society (Dortmund, Germany). In 2012, Christian Ottmann was appointed Associate Professor of Molecular and Structural Cell Biology at the department of Biomedical Engineering of Eindhoven University of Technology (TU/e). In that same year he was recipient of the Innovation Award in Medicinal/Pharmaceutical Chemistry of the Gesellschaft Deutscher Chemiker and the Deutsche Pharmazeutische Gesellschaft. In 2013, Christian Ottmann received the Young Chemical Biologist Award of the International Chemical Biology Society (ICBS). In 2014 he was appointed professor at the Institute for Organic Chemistry of the University of Duisburg-Essen (Germany).
Recent Publications
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Markella Konstantinidou,Emira J. Visser,Edmee Vandenboorn,Sheng Chen,Priyadarshini Jaishankar,Shubhankar Dutta,R. Jeffrey Neitz,Adam R. Renslo,Christian Ottmann,Luc Brunsveld
Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments
Journal of the American Chemical Society (2023) -
Emira J. Visser,Priyadarshini Jaishankar,Eline Sijbesma,Marloes A.M. Pennings,Edmee M.F. Vandenboorn,Xavier Guillory,R. Jeffrey Neitz,John Morrow,Shubhankar Dutta,Adam R. Renslo
From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking
Angewandte Chemie - International Edition (2023) -
Bente A. Somsen,Eline Sijbesma,Seppe Leysen,Karolina Honzejkova,Emira J. Visser,Peter J. Cossar,Tomáš Obšil,Luc Brunsveld,Christian Ottmann
Molecular basis and dual ligand regulation of tetrameric Estrogen Receptor α/14-3-3ζ protein complex
Journal of Biological Chemistry (2023) -
Blaz Andlovic,Geronimo Heilmann,Sabrina Ninck,Sebastian A Andrei,Federica Centorrino,Yusuke Higuchi,Nobuo Kato,Luc Brunsveld,Michelle Arkin,Sascha Menninger
IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization
Cell Chemical Biology (2023) -
Dyana N. Kenanova,Emira J. Visser,Johanna M. Virta,Eline Sijbesma,Federica Centorrino,Holly R. Vickery,Mengqi Zhong,R. Jeffrey Neitz,Luc Brunsveld,Christian Ottmann
A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers
ACS Central Science (2023)
Ancillary Activities
- R&D, CTO